Journal Information
Vol. 102. Issue 2.
Pages 86-97 (March 2011)
Share
Share
Download PDF
More article options
Vol. 102. Issue 2.
Pages 86-97 (March 2011)
Full text access
Allergic Contact Dermatitis Caused by Formaldehyde and Formaldehyde Releasers
Dermatitis de contacto alérgica por formaldehído y liberadores de formaldehído
Visits
8507
N. Latorre
Corresponding author
, J.F. Silvestre, A.F. Monteagudo
Sección de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain
This item has received
Article information
Abstract

Formaldehyde is a colorless gas with a pungent odor that is widely used as a preservative in toiletries and cosmetics and in products for household and industrial use. Both formaldehyde itself and substances that can release it are a common cause of allergic contact dermatitis. This condition often becomes chronic, given that these allergens are found nearly everywhere and it is difficult for patients to avoid them completely. This article reviews the sources of exposure to formaldehyde and formaldehyde releasers and the clinical manifestations of allergen exposure. We also review current debates and recent developments and propose guidelines for the diagnosis and treatment of patients with formaldehyde contact dermatitis.

Keywords:
Allergic contact dermatitis
Formaldehyde
Formaldehyde releasers
Patch tests
Resumen

El formaldehído es un gas incoloro de olor penetrante que se emplea como conservante en gran cantidad de productos de higiene y cosméticos, domésticos y de aplicación industrial. Tanto el formaldehído como las sustancias capaces de liberar formaldehído son una causa común de dermatitis de contacto alérgica que, a menudo, se cronifica dada la dificultad que tienen los pacientes alérgicos para evitar por completo estos alérgenos de distribución tan ubicua. El presente artículo pretende repasar las fuentes de exposición a formaldehído y liberadores de formaldehído, las manifestaciones clínicas generadas por estos alérgenos y las controversias y novedades existentes respecto a este tema en la actualidad. Además proponemos unas pautas para el diagnóstico y el tratamiento de estos pacientes.

Palabras Clave:
Dermatitis de contacto alérgica
Formaldehído
Liberadores de formaldehido
Pruebas epicutáneas
Full text is only aviable in PDF
References
[1.]
B. García-Bravo, L. Conde-Salazar, J. De la Cuadra, V. Fernández-Redondo, J.M. Fernández Vozmediano, D. Guimaraens, et al.
Estudio epidemiológico de la dermatitis alérgica de contacto en España (2001).
Actas Dermosifiliogr, 95 (2004), pp. 14-24
[2.]
A. Scheman, S. Jacon, M. Zirwas, E. Warshaw, S. Nedorost, R. Katta, et al.
Contact allergy: Alternatives for the 2007 North American Dermatitis Group (NACDG) standard screening tray.
[3.]
M.-A. Flyvholm.
Formaldehyde exposure at the workplace and in the environment.
Allergologie, 20 (1997), pp. 225-231
[4.]
M.-A. Flyvholm, T. Menné.
Allergic contact dermatitis from formaldehyde A case study focussing on sources of formaldehyde exposure.
Contact Dermatitis, 27 (1992), pp. 27-36
[5.]
C. Hebert, R.L. Rietschel.
Formaldehyde and formaldehyde releasers: how much avoidance of cross-reacting agents is required?.
Contact Dermatitis, 50 (2004), pp. 371-373
[6.]
M. Kireche, E. Giménez-Arnau, J.-P. Lepoittevin.
Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers toward amino acids through breakdown products other than formaldehyde.
Contact Dermatitis, 63 (2010), pp. 192-202
[7.]
A.C. De Groot, I.R. White, M.-A. Flyvholm, G. Lensen, P.-J. Coenraads.
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics.
Contact Dermatitis, 62 (2010), pp. 2-17
[8.]
E. Tegner, S. Fregert.
Contamination of cosmetics with formaldehyde from tubes.
Contact Dermatitis Newsl, 13 (1973), pp. 353
[9.]
S. Fregert.
Contamination of chemico-technical preparations with formaldehyde from packages.
Contact Dermatitis, 3 (1977), pp. 109-110
[10.]
M. Bergh, K. Magnusson, J.L.G. Nilsson, A.-T. Kalberg.
Formation of formaldehyde and peroxides by air oxidation of high purity polyoxyethylene surfactants.
Contact Dermatitis, 39 (1998), pp. 14-20
[11.]
M. Bergh, K. Magnusson, J.L.G. Nilsson, A.T. Kalbeg.
Contact allergenic activity of Tween 80 before and after air exposure.
Contact Dermatitis, 37 (1997), pp. 9-18
[12.]
A. Goon, B. Gruvberger, L. Persson, M. Isaksson, M. Bruze.
Presence of formaldehyde in topical corticosteroid preparations available on the Swedish market.
Contact Dermatitis, 48 (2003), pp. 199-203
[13.]
C. Timmer.
Antimicrobials and disinfectants.
Handbook of occupational dermatology, pp. 462-473
[14.]
J.A. Sheperd, R.D. Waigh, P. Gilbert.
Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol).
Antimicrob Agents Chemother, 32 (1988), pp. 1693-1698
[15.]
A.C. De Groot, T. van Joost, J.D. Bos, H.L.M. Van der Meeren, J.W. Weyland.
Patch test reactivity to DMDM hydantoin Relationship to formaldehyde.
Contact Dermatitis, 18 (1988), pp. 197-201
[16.]
A.C. De Groot, M.A. Flyvholm.
Formaldehyde-releasers: relationship to formaldehyde contact allergy Contact allergy to formaldehyde and inventory of formaldehyde-releasers.
Contact Dermatitis, 61 (2009), pp. 63-85
[17.]
M. Rosen, A. McFarland.
Free formaldehyde in anionic shampoos.
J Soc Cosmet Chem., 35 (1984), pp. 157-169
[18.]
D. Emeis, W. Anker, K.-P. Wittern.
Quantitative 13 C NMR Spectroscopic studies on the equilibrium of formaldehyde with its releasing cosmetic preservatives.
Anal Chem., 79 (2007), pp. 2096-2100
[19.]
C. Zachariae, B. Hall, M. Cottin, S. Cupperman, K.E. Andersen, T. Menné.
Experimental elicitation of contact allergy from a diazolidinyl urea-preserved cream in relation to anatomical region, exposure time and concentration.
Contact Dermatitis, 53 (2005), pp. 268-277
[20.]
A.-T. Karlberg, L. Skare, I. Lindberg, E. Nyhammer.
A method for quantification of formaldehyde in the presence of formaldehyde donors in skin-care products.
Contact Dermatitis, 38 (1998), pp. 20-28
[21.]
H. Engelhardt, R. Klinkner.
Determination of free formaldehyde in the presence of donators in cosmetics by HPLC and post-column derivation.
Chromatographia, 20 (1985), pp. 559-565
[22.]
A. De Groot, I.R. White, M.A. Flyvholm, G. Lensen, P.-J. Coenrads.
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde.
Contact Dermatitis, 62 (2010), pp. 18-31
[23.]
J. García-Gavín, D. González-Vilas, V. Fernández-Redondo, J. Toribo.
Allergic contact dermatitis in a girl due to several cosmetics containing diazolidinyl-urea or imidazolidinyl-urea.
Contact Dermatitis, 63 (2010), pp. 49-50
[24.]
M.D. Lundov, J.D. Johansen, B.C. Carlsen, K. Engkilde, T. Menné, J.P. Thyssen.
Formaldehyde exposure and patterns of concomitant contact allergy to formaldehyde and formaldehyde-releasers.
Contact Dermatitis, 63 (2010), pp. 31-36
[25.]
B.N. Statham, E.V. Smith, O.G. Bodger, C.M. Green, C.M. King, A.D. Ormerod, et al.
Concomitant contact allergy to methylchloroisothiazolinone/methylisothiazolinone and formaldehyde-releasing preservatives.
Contact Dermatitis, 62 (2010), pp. 56-57
[26.]
K.E. Andersen, I.R. White, A. Goossens.
Allergens from the Standard Series.
Contact Dermatitis, pp. 453-492
[27.]
A. De Groot, H.I. Maibach.
Does allergic contact dermatitis from formaldehyde in clothes treated with durable-press chemical finishes exist in the USA?.
Contact Dermatitis, 62 (2010), pp. 127-136
[28.]
C.M. Owen, M.H. Beck.
Occupational allergic contact dermatitis from phenol formaldehyde resins.
Contact Dermatitis, 45 (2001), pp. 294-295
[29.]
E. Zimerson, M. Bruze.
Contact allergy to the monomers in p-tert-butylphenol formaldehyde resin.
Contact Dermatitis, 47 (2002), pp. 147-153
[30.]
K. Aalto-Korte, E.A. Makela, M. Huttunen, K. Suuronen, R. Jolanki.
Occupational contact allergy to glyoxal.
Contact Dermatitis, 52 (2005), pp. 276-281
[31.]
W. Uter, H.J. Schwanitz, H. Lessmann, A. Schnuch.
Glyoxal is an important allergen for (medical care) cleaning staff.
Int J Hyg Environ Health, 204 (2001), pp. 251-253
[32.]
Eighth Commission Directive 86/199/EC of 26 March 1986 adapting to technical progress Annexes II , IV and V to Council Directive 76/768/EC on the approximation of the laws of the Member States relating to cosmetics products. Off J Eur Commun L. 1986; 149:38–45.
[33.]
A. De Groot, M. Veenstra.
Formaldehyde-releasers in cosmetics in the USA and in Europe.
Contact Dermatitis, 62 (2010), pp. 221-224
[34.]
C.M. Perrett, R. Happle.
Contact sensitivity to diazolidinyl urea (Germall II).
Arch Dermatol Res, 281 (1989), pp. 57-59
[35.]
K. Aalto-Korte, O. Kuuliala, K. Suuronen, K. Alanko.
Occupational contact allergy to formaldehyde and formaldehyde releasers.
Contact Dermatitis, 59 (2008), pp. 280-289
[36.]
R.L. Rietschel, E.M. Warshaw, D. Sasseville, J.F. Fowler Jr., V.A. DeLeo, D.V. Belsito, et al.
Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydanto a retrospective analysis from the North American Contact Dermatitis Group.
Dermatitis, 18 (2007), pp. 155-162
[37.]
M.-C. Jacobs, I.R. White, R.J.G. Rycroft, N. Taub.
Patch testing with preservatives at St John's from 1982 to 1993.
Contact Dermatitis, 33 (1995), pp. 247-254
[38.]
A.F. Fransway, N.A. Schmitz.
The problem of preservation in the 1990 s: II Formaldehyde and formaldehyde-releasing biocides: incidences of cross-reactivity and the significance of the positive response to formaldehyde.
Am J Contact Dermatitis, 2 (1991), pp. 78-88
[39.]
H. Ebner, D. Kraft.
Formaldehyde induced anaphylaxis alter dental treatment?.
Contact Dermatitis, 24 (1991), pp. 307
[40.]
S.E. Jacab, S. Stechschulte.
Formaldehyde, aspartame, and migraines: a possible connection.
Dermatitis, 19 (2008), pp. E10-E11
[41.]
E. Cronin.
Formaldehyde is a significant allergen in women with hand eczema.
Contact Dermatitis, 25 (1991), pp. 276-282
[42.]
T. Agner, M.-A. Flyvholm, T. Menné.
Formaldehyde allergy: A follow-up study.
Am J Contact Dermat, 10 (1999), pp. 12-17
[43.]
D. Cohen, K.L. Hatch, H.I. Maibach, M. Pratt.
Clothes make the (wo) man: diagnosis and management of clothing dermatitis.
Am J Contact Dermatitis, 12 (2001), pp. 229-231
[44.]
B.C. Carlsen, T. Menné, J.D. Johansen.
20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies.
Contact Dermatitis, 57 (2007), pp. 76-83
[45.]
A. Trattner, J.D. Johansen, T. Menn.
Formaldehyde concentration in diagnostic patch testing: comparison of 1% with 2%.
Contact Dermatitis, 38 (1998), pp. 9-13
[46.]
B. Gruvberger, M. Bruze, S. Fregert, C. Lidén.
Allergens exposure assessment.
Contact dermatitis, 4th ed, pp. 413-427
[47.]
M. Gryllaki-Berger, C. Mugny, D. Perrenoud, A. Pannater, E. Frenk.
A comparative study of formaldehyde detection using chromotropic acid, acetylacetone and HPLC in cosmetics and household cleaning products.
Contact Dermatitis, 26 (1992), pp. 149-154
[48.]
M.-A. Flyvholm, E. Tiedemann, T. Menné.
Comparison of 2 tests for clinical assessment of formaldehyde exposure.
Contact Dermatitis, 34 (1996), pp. 35-38
[49.]
S. Fregert, I. Dahlquist, B. Gruvberger.
A simple method for the detection of formaldehyde.
Contact Dermatitis, 10 (1984), pp. 132-134
[50.]
C.A. Benassi, A. Semenzato, A. Bettero.
High-performance liquid chromatographic determination of free formaldehyde in cosmetics.
J Chromatogr, 464 (1989), pp. 387-393
[51.]
S. Selim.
Separation and quantitative determination of traces of carbonyl compounds as their 2,4-dinitrophenylhydrazones by high-pressure liquid chromatography.
J Chromatogr, 136 (1977), pp. 271-277
[52.]
EC Commissions Directive of 4th April 1990 (90/207/EC): Identification and determination of free formaldehyde. Official Journal of the EC. 1990; L108 28.4:92–101.
[53.]
D.M. Pasad, C.L. Cochran.
Optimization of the AATCC sealed jar and HPLC methods for measurement of low levels of formaldehyde.
Text Chem Colorist, 21 (1989), pp. 13-18
[54.]
American Association of Textile Chemists and Colorists. Technical Manual. Research Manual Park: American Association of Textile Chemists and Colorists; 1997.
Copyright © 2011. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Download PDF
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?